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IMAGE OF THE MONTH
Year : 2020  |  Volume : 1  |  Issue : 1  |  Page : 40

Ac 225 quinoline theragnosis in recurrent advanced ovarian cancer


Department of Nuclear Medicine and Imaging, HCG Cancer Centre, India

Date of Web Publication22-Oct-2020

Correspondence Address:
Dr. K Kallur
Department of Nuclear Medicine and Imaging, HCG Cancer Centre, Bangaluru
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/WKMP-0197.298283

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How to cite this article:
Kallur K, Prasanth. Ac 225 quinoline theragnosis in recurrent advanced ovarian cancer. J Precis Oncol 2020;1:40

How to cite this URL:
Kallur K, Prasanth. Ac 225 quinoline theragnosis in recurrent advanced ovarian cancer. J Precis Oncol [serial online] 2020 [cited 2020 Nov 25];1:40. Available from: https://www.jprecisiononcology.com/text.asp?2020/1/1/40/298283





A case of Carcinoma Ovary presented to us in January, 2015 with metastatic disease. She was treated with Chemotherapy with complete response.

In November 2016, when she relapsed, standard chemotherapy regimen was started. However, there was no significant benefit. The disease progressed and developed Ascites requiring Ascitic tap twice a week. A novel regimen of Ac 225- Quinoline derivative therapy with three courses of weekly Cisplatin and with significant response (Figure). The ascites reduced and her lesion regressed completely achieving complete response. Today, patient has a good quality of life and doing well.


  Discussion Top


Ac 225 Quinoline derivative targets the tumour stroma. Ac 225 is an Alpha emitting isotope with 10 days half-life [1]. Ac 225 linked to Quinoline derivative selectively targets cancer associated fibroblasts (CAF) in the tumour. It is highly specific and targets the CAF which are found only in the malignant tissue. As a result, there is no non-specific uptake of the isotope elsewhere in the body. The side effects are limited considering the high specificity. CAF have been implicated in resistance to chemotherapy. When this stroma is destroyed by the alpha radiation, the tumour becomes responsive to chemotherapy.



 
  References Top

1.
Morgenstern A, Apostolidis C, Kratochwil C, et al. An Overview of Targeted Alpha Therapy with225 Actinium and213 Bismuth. Curr Radiopharm. 2018;11(3):200-208. doi:10.2174/1874471011666180502104524  Back to cited text no. 1
    




 

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